Distinct 11C-ER176 PET Neuroinflammatory Profiles and Tau Colocalization in Progressive Apraxia of Speech With and Without Parkinson-plus Syndrome
11C-ER176 PET analysis demonstrates neuroinflammation in frontal and subcortical regions in PAOS which is particularly severe and widespread with the development of Parkinson-plus clinical features. The colocalization of neuroinflammation and tau may support a relationship between these disease mechanisms.
Authors
- Val J. Lowe (ORCID: https://orcid.org/0000-0002-5612-1667)
- Heather M. Clark (ORCID: https://orcid.org/0000-0001-9697-0084)
- Joseph R. Duffy (ORCID: https://orcid.org/0000-0001-8206-3432)
- Keith A. Josephs (ORCID: https://orcid.org/0000-0003-2930-8634)
- Rene L. Utianski (ORCID: https://orcid.org/0000-0001-9519-1302)
- Rosa Rademakers (ORCID: https://orcid.org/0000-0002-4049-0863)
- Matt Baker
- Yehkyoung C. Stephens (ORCID: https://orcid.org/0000-0003-0761-3283)
- Jeyeon Lee (ORCID: https://orcid.org/0000-0003-2709-7642)
- Ryota Satoh (ORCID: https://orcid.org/0000-0002-3418-2987)
- Jennifer L. Whitwell
Institutions
- University of Antwerp (BE)
- Mayo Clinic in Arizona (US)
- VIB-UAntwerp Center for Molecular Neurology (BE)
- Mayo Clinic in Florida (US)
- Hanyang University (KR)
Publication Details
- Journal
- Clinical Nuclear Medicine
- Published
- 2025-06-30
- DOI
- https://doi.org/10.1097/rlu.0000000000005962
- Citations
- 1
- Primary Topic
- Neurobiology of Language and Bilingualism
- Type
- article
- Field-Weighted Citation Impact
- 1.43