Current Unveiling Key Research Trends in Endometrial Cancer: A Comprehensive Topic Modeling Analysis

<b>Background/Objectives:</b> Endometrial cancer (EC) is the sixth most common cancer among women worldwide, and its global incidence has significantly increased over the past three decades. Despite its substantial burden, comprehensive reviews of EC-related research remain limited. This study employs topic modeling to analyze and classify recent research trends in EC. <b>Methods:</b> We identified studies related to endometrial carcinoma published between 2019 and 2023 in PubMed, Web of Science, and the Cochrane Library. The search was conducted using the following terms: endometr* AND (neoplasm* OR cancer* OR carcinoma*) NOT endometriosis. Word clouds were constructed and topic modeling was performed to analyze research activity. <b>Results:</b> A total of 2188 studies were selected, and 11,552 terms were extracted. High-frequency and TF-IDF-weighted keywords included 'cancer', 'risk', 'survival', 'stage', 'tumor', 'surgery', and 'OS.' Topic modeling analysis identified ten clusters, categorized as follows: 'Gynecologic cancer', 'Surgical staging', 'Therapeutic efficacy', 'Diagnosis', 'Surgical management', 'Multimodal treatment', 'Molecular treatment', 'Risk factors', 'Survival', and 'Hormonal regulation.' <b>Conclusions:</b> This study highlights that recent research on EC has primarily focused on surgical decision making, outcome prediction, and patient survival. Future studies should place greater emphasis on multimodal treatment and prevention-particularly through the identification of risk factors-as well as on improving patients' quality of life.