Circulating Proteins for Prediction of Kidney Disease Progression and Cardiovascular Outcomes: Individual Participant Data Meta-Analysis of Four Cohorts
KIM-1, TNFRSF1A, and TNFRSF1B may not be strong prognostic enrichment biomarkers over and above clinical risk estimates. Clinical trials should test whether they help with predictive enrichment.
Authors
- Ruth F. Dubin (ORCID: https://orcid.org/0000-0002-0498-1980)
- Ramachandran Srini Vasan (ORCID: https://orcid.org/0000-0001-7357-5970)
- Sarah J. Schrauben (ORCID: https://orcid.org/0000-0003-2557-5161)
- Eugene P. Rhee (ORCID: https://orcid.org/0000-0002-4804-7583)
- Carolina Lopez-Silva
- Morgan E. Grams (ORCID: https://orcid.org/0000-0002-4430-6023)
- Matthew R. Weir (ORCID: https://orcid.org/0000-0001-8820-5702)
- Aditya Surapaneni (ORCID: https://orcid.org/0000-0003-4978-5980)
- Chirag R. Parikh (ORCID: https://orcid.org/0000-0001-9051-7385)
- Pascal Schlosser (ORCID: https://orcid.org/0000-0002-8460-0462)
- Teresa K. Chen (ORCID: https://orcid.org/0000-0003-0106-050X)
- Insa Marie Schmidt (ORCID: https://orcid.org/0000-0002-0420-6570)
- Rajat Deo (ORCID: https://orcid.org/0000-0002-8250-2607)
- Mirela Dobre (ORCID: https://orcid.org/0000-0002-9059-9998)
- Sushrut S. Waikar (ORCID: https://orcid.org/0000-0003-4004-326X)
- Peter Ganz (ORCID: https://orcid.org/0000-0002-0437-8882)
- Ana Catherine Ricardo (ORCID: https://orcid.org/0000-0001-8670-3644)
- Panduranga S. Rao (ORCID: https://orcid.org/0000-0002-4699-5395)
- Joseph Vincent Bonventre (ORCID: https://orcid.org/0000-0001-7144-386X)
- Josef Coresh (ORCID: https://orcid.org/0000-0002-4598-0669)
- Paul L. Kimmel
Institutions
- Boston University (US)
- University of Maryland, Baltimore (US)
- Brigham and Women's Hospital (US)
- Johns Hopkins University (US)
- University of Freiburg (DE)
- The University of Texas at San Antonio Health Science Center (US)
- University of California, San Francisco (US)
- University of Michigan (US)
- University Hospitals of Cleveland (US)
- Hospital of the University of Pennsylvania (US)
- Johns Hopkins Medicine (US)
- University Medical Center Freiburg (DE)
- University of Illinois Chicago (US)
- Massachusetts General Hospital (US)
- National Institute of Diabetes and Digestive and Kidney Diseases (US)
- Quantitative BioSciences (US)
- Michigan Medicine (US)
- Precision for Medicine (United States) (US)
- San Francisco VA Health Care System (US)
- New York University (US)
- University of San Francisco (US)
- University of Pennsylvania (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- American Journal of Nephrology
- Published
- 2025-06-30
- DOI
- https://doi.org/10.1159/000547138
- Primary Topic
- Chronic Kidney Disease and Diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Health and Human Services
- National Institutes of Health
- National Heart, Lung, and Blood Institute