Punctate Podocyte IgG Staining Does Not Differentiate Primary from Secondary Minimal Change Disease

Podocyte IgG dusting was not specific for any one etiologic trigger of MCD or age category. This suggests that autoantibodies may induce MCD irrespective of a primary (idiopathic) versus a presumed secondary cause, which may alter the diagnostic and therapeutic approach. Additionally, podocyte ultrastructural features associated with dusting may reflect mechanisms of autoantibody-induced injury, or may represent a feature of disease severity and/or temporal progression.