Design and Application of a Multi-Mode Signal Codetection System for Brain Signals
We present a multi-mode signal co-detection system integrating electrophysiology and electrochemical techniques, enabling simultaneous recording of neural and dopamine signals in real time from awake animals. The system features an integrated headstage with significantly reduced noise—only 32.8% of that found in commercial equipment (PalmSens4). The electrode, modified with PEDOT:PSS/IrOx, boasts a high charge storage capacity (CSC) of <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$36.3 \text{mC} / \text{cm}^{2}$</tex> and excellent dopamine sensitivity at <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$21.86 \text{pA} / \mu \mathrm{M}$</tex>, enhancing electroactive neurotransmitter detection.
Authors
- Zhitao Zhou (ORCID: https://orcid.org/0000-0003-4277-4461)
- Dujuan Zou
- Guangdong Zhou (ORCID: https://orcid.org/0000-0003-2488-2733)
- Tiger H. Tao (ORCID: https://orcid.org/0000-0002-6583-5039)
- Huiran Yang (ORCID: https://orcid.org/0000-0003-2094-4394)
- Xiaoling Wei (ORCID: https://orcid.org/0000-0002-0099-2260)
- Zhengyu Liang (ORCID: https://orcid.org/0000-0002-3307-0959)
- Xueying Wang (ORCID: https://orcid.org/0000-0001-6445-8887)
- Ziyi Zhu
- Siyuan Ni
- Liuyang Sun
- Jianbo Jiang
Institutions
- State Key Laboratory of Transducer Technology (CN)
- Shanghai Institute of Microsystem and Information Technology (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Published
- 2025-03-09
- DOI
- https://doi.org/10.1109/edtm61175.2025.11041691
- Primary Topic
- Neuroscience and Neural Engineering
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Shanghai Rising-Star Program
- Youth Innovation Promotion Association