TLR9 gene polymorphism -1237T/C (rs5743836) is associated with low IgG antibody response against PvCSP variants in symptomatic P. vivax infections in Venezuela
These findings suggest that TLR9 gene variability, particularly the heterozygous genotype for SNP rs5743836, may influence the IgG antibody response against PvCSP VK247 and V-like. Identifying genetic traits that impact immune response development could be valuable for malaria vaccine design and implementation.
Authors
- Eva Salazar-Alcalá (ORCID: https://orcid.org/0000-0002-9326-4202)
- David A. Forero‐Peña (ORCID: https://orcid.org/0000-0002-8065-8464)
- Mary Lopez-Perez (ORCID: https://orcid.org/0000-0002-9876-0248)
- Mercedes Fernández‐Mestre (ORCID: https://orcid.org/0000-0001-6227-5884)
- Fhabián S. Carrión‐Nessi (ORCID: https://orcid.org/0000-0003-4415-8646)
- Kellys A Curiel
Institutions
- University of Copenhagen (DK)
- Instituto Venezolano de Investigaciones Científicas (VE)
- Hospital Clínico Universitario de Caracas (VE)
- Universidad Central de Venezuela (VE)
Publication Details
- Journal
- PLoS neglected tropical diseases
- Published
- 2025-06-30
- DOI
- https://doi.org/10.1371/journal.pntd.0013262
- Primary Topic
- Respiratory viral infections research
- Type
- article
- Field-Weighted Citation Impact
- 0.00