PROGNOSTIC VALUE OF URINARY ALBUMIN-TO-CREATININE RATIO IN A SURGICAL PRACTICE

Background. The urinary albumin-to-creatinine ratio is a well-established marker of early kidney damage, endothelial dysfunction, and systemic inflammation. Elevated urinary albumin-to-creatinine ratio levels are linked to increased cardiovascular risk and mortality. During surgical stress, urinary albumin-to-creatinine ratio may reflect vascular and inflammatory changes, yet its prognostic value in surgical patients remains insufficiently studied. Objective: To assess the prognostic significance of urinary albumin-to-creatinine ratio in patients undergoing surgical interventions. Materials and Methods. A retrospective analysis included 171 patients (98 men, 73 women) aged 40–70 years who underwent various surgeries at the National Scientific Center of Surgery named after A.N. Syzganov from March 2022 to March 2025. Random morning urine samples were analyzed for albumin and creatinine, and urinary albumin-to-creatinine ratio was calculated. Measurements were performed using Cobas 303 and 311 analyzers (Roche Diagnostics). Results. The mean age was 53.2 years. Mean urinary creatinine and albumin were 186.67 mmol/L and 243.73 mg/L, with median values of 9.62 mmol/L and 14.7 mg/L, respectively. Median urinary albumin-to-creatinine ratio was 1.72 mg/mmol; mean was 39.72 mg/mmol, indicating skewness. No significant correlation was found between albumin and creatinine (ρ = –0.037; p = 0.631). A moderate, non-significant inverse correlation was observed in the high-level subgroup (n = 6). Conclusion. Although overall correlations were not significant, findings suggest that urinary albumin-to-creatinine ratio may have prognostic potential. Further prospective studies are needed, especially in abdominal surgery settings.