Does Gut Microbiota Modulation Offer a Pathway to Manage Celiac Disease?

Celiac disease is a significant life-long health condition with an estimated prevalence of 0.5 to 1 percent globally.Celiac disease is caused by an autoimmune abnormal response of the body to ingestion of gluten.Individuals experiencing Celiac Disease experience varying degrees of quality of life depending on their circumstances.Strict dietary restrictions and/or regular use of probiotics can be challenging due to issues in availability and cost.The main treatment strategy for Celiac Disease is a gluten-free diet which has limited compliance.Several proxy strategies have been tested over the years including prebiotics, probiotics, and post-biotics providing various types of alterations in gut microbiome designed to modulate the autoimmune response to gluten and its components.The current paper focuses on the therapeutic manipulation of gut microbiome to facilitate the management of Celiac Disease.It also discusses the known mechanisms by which gut microbiota influence various other body systems and the factors that influence these complex interactions.The limitations of the papers reviewed have consistently shown the need for further research to fully elucidate the molecular underpinning and understanding of the long-term impact of the use of probiotics and intestinal microbes on the human body.