Mendelian Randomization Study Evidence On The Association Between Herpes Simplex Virus Antibodies Immune Response And The Risk Of Drug-Induced Obesity

This study utilized Mendelian randomization (MR) to investigate the causal link between immune response to herpes simplex virus antibodies and drug-induced obesity (DIO). Genome-wide association study (GWAS) data was analyzed using methods like Inverse Variance Weighted (IVW), MR-Egger, and Weighted Median method (WME). Effective instrumental variables were identified, showing a significant increase in DIO risk with Epstein-Barr virus ZEBRA antibody, herpes simplex virus 7 U14 antibody, herpes simplex virus type 1 IgG, and herpes simplex virus type 2 IgG seropositivity. Reverse MR analysis did not reveal a reverse causal relationship. The study provides initial evidence of the relationship between herpes simplex virus antibody immune response and DIO, contributing new theoretical insights for future understanding of DIO.