Pathogenetic Approach to the Use of a Non-hormonal Drug for Correction of Experimental Thyroid Pathology

Today, hypothyroidism of various origins affects about 10% of the Earth's population. The relevance of this work is due to the absence of original harmless and effective natural products on the domestic and global pharmaceutical market, which can be used both to normalize the immune system and to restore the functional activity of the thyroid gland and reduce the level of associated complications. In modern endocrinology, fetal biological products, including cord blood products, can be a certain alternative to replacement therapy (or in combination with it). The aim of the work was to find new therapeutic approaches for the correction of the most common thyropathies. The study was conducted on 75 sexually mature male Wistar rats in a model of autoimmune hypothyroidism, which developed in rats against the background of autoimmune thyroid damage, which was caused by immunizing animals with thyroid antigen in combination with Freund's complete adjuvant. The animals were injected with a cryopreserved cord blood preparation "Cryocell-Cryocord" (CC) and a reference preparation "L-thyroxine" (LT4) (Berlin-Chemie, Germany). The AIH model leads to persistent pathological changes in the structure and function of the thyroid gland and immunological disorders. It was determined that at all times of the study, the biological preparation of СС had a positive effect on the restoration of the hormone-producing function of the thyroid gland in rats with AIH, increasing the content of both fractions of thyroid hormones, i.e. the biological preparation of СС showed itself as a powerful stimulator of the hormone-producing function of the thyroid gland. In addition, the use of the cord blood preparation significantly reduced the titer of antithyroid antibodies. The normalizing effect of СС on the indicators of specific humoral and cellular immunity was maintained throughout the experiment, which indicated the effectiveness of its use in thyroid pathologies. The multipotent properties of СС allow us to consider this biological preparation as a promising potential tool in the complex therapy of hypothyroidism of various genesis. The use of such approaches in the therapy of thyroid dysfunction is pathogenetically justified.