HER2-low expression in patients with hormone receptor positive and HER2 negative advanced breast cancer treated with ribociclib or palbociclib in combination with endocrine therapy
Aim: Hormone receptor (HR)-positive, human epidermal growth factor 2 (HER2)-negative breast cancer which represents the most common subgroup of metastatic breast cancer (MBC). Recently, further subclassification for HER2-negative tumors has emerged as HER2-low. There is limited knowledge regarding the effect of HER2-low expression on outcomes of patients with HR-positive and HER2-negative MBC treated with CDK 4/6 inhibitors plus hormonal therapy. Therefore, we evaluated survival parameters according to HER2-low status for this patient group in this study. Material and Methods: As the Turkish Oncology Group (TOG) Project, retrospectively collected data from 423 patients with HR-positive/HER2-negative MBC treated with ribociclib and palbociclib plus letrozole therapy was assessed. Included patients had metastatic first-line therapy and endocrine-sensitive disease. Survival outcomes were compared between HER2-negative and HER2-low patient groups. Conclusion: HER2-low status had no statistically significant impact on survival in patients treated with palbociclib or ribociclib plus letrozole.
Authors
- Merve Keskinkılıç (ORCID: https://orcid.org/0000-0002-3342-3144)
- İbrahim Vedat Bayoğlu (ORCID: https://orcid.org/0000-0002-0481-1084)
- Hacer Demir (ORCID: https://orcid.org/0000-0003-1235-9363)
- Naziyet Köse Baytemür (ORCID: https://orcid.org/0000-0002-3587-2517)
- Semra Paydaş (ORCID: https://orcid.org/0000-0003-4642-3693)
- Hakan Yücel (ORCID: https://orcid.org/0000-0003-4711-1405)
- Burçin Çakan Demirel (ORCID: https://orcid.org/0000-0003-0734-0692)
- Cihan Erol (ORCID: https://orcid.org/0000-0003-3155-8798)
- Eda Eylemer Mocan (ORCID: https://orcid.org/0000-0003-0429-8142)
- Seda Kahraman (ORCID: https://orcid.org/0000-0002-5328-6554)
- Arzu Yaren (ORCID: https://orcid.org/0000-0003-1436-8650)
- Gül Başaran (ORCID: https://orcid.org/0000-0002-0775-6180)
- Aydın Dincer (ORCID: https://orcid.org/0000-0002-0662-512X)
- Burak Bi̇lgi̇n (ORCID: https://orcid.org/0000-0003-1717-8246)
- Kerem Okutur (ORCID: https://orcid.org/0000-0002-8079-7739)
- Nurhan Önal Kalkan (ORCID: https://orcid.org/0000-0002-2823-332X)
- Ömer Acar (ORCID: https://orcid.org/0000-0003-4408-1976)
- Özgecan Dülgar (ORCID: https://orcid.org/0000-0002-0678-4024)
- Özge Gümüşay (ORCID: https://orcid.org/0000-0002-6236-9829)
- Atike Pınar Erdoğan (ORCID: https://orcid.org/0000-0003-4859-7574)
- İlhan Hacıbekiroğlu (ORCID: https://orcid.org/0000-0002-0333-7405)
- Ali İnal (ORCID: https://orcid.org/0000-0001-9510-9858)
- Orhan Önder Eren (ORCID: https://orcid.org/0000-0001-6397-8207)
- Murat Keser (ORCID: https://orcid.org/0000-0003-3834-0863)
- Erdem Çubukçu (ORCID: https://orcid.org/0000-0002-0070-0889)
- Yusuf Karakaş (ORCID: https://orcid.org/0000-0003-0205-4590)
- Adnan Aydıner (ORCID: https://orcid.org/0000-0002-1104-5840)
- Burcu Gülbağcı (ORCID: https://orcid.org/0000-0002-5720-8254)
- Teoman Şakalar (ORCID: https://orcid.org/0000-0003-2749-9414)
- Mehmet Alı Nahıt Şendur (ORCID: https://orcid.org/0000-0001-7021-6139)
- Musa Barış Aykan (ORCID: https://orcid.org/0000-0001-7538-9119)
- Yakup İriağaç (ORCID: https://orcid.org/0000-0001-7411-1705)
- Mutlu Hızal (ORCID: https://orcid.org/0000-0001-5147-4431)
- Nail Paksoy (ORCID: https://orcid.org/0000-0003-4636-2595)
- Mustafa Seyyar (ORCID: https://orcid.org/0000-0002-4841-7994)
- Özlem Doğan (ORCID: https://orcid.org/0000-0003-1023-8410)
- Umut Demırcı (ORCID: https://orcid.org/0000-0002-4833-6721)
- Erkan Kayıkçıoğlu (ORCID: https://orcid.org/0000-0002-7401-5446)
- Nazım Serdar Turhal (ORCID: https://orcid.org/0000-0002-1013-5676)
- Bülent Çetin (ORCID: https://orcid.org/0000-0001-8628-0864)
- Ertuğrul Bayram (ORCID: https://orcid.org/0000-0001-8713-7613)
- Berna Bozkurt Duman
- Veli Sunar (ORCID: https://orcid.org/0000-0003-4672-4621)
- Melike Özçelik (ORCID: https://orcid.org/0000-0003-0406-715X)
- Fatih Selçukbırıcık (ORCID: https://orcid.org/0000-0002-1273-1674)
- Esra Aydın (ORCID: https://orcid.org/0000-0003-0210-3153)
- Mutlu Doğan (ORCID: https://orcid.org/0000-0001-9359-3770)
- Muhammed Muhiddin Er (ORCID: https://orcid.org/0000-0002-0583-0295)
- Başak Oyan Uluç (ORCID: https://orcid.org/0000-0002-6623-6273)
- Devrim Çabuk (ORCID: https://orcid.org/0000-0002-7871-6311)
- Deniz Işık (ORCID: https://orcid.org/0000-0003-4398-5148)
- Muhammed Bülent Akıncı (ORCID: https://orcid.org/0000-0001-7575-9925)
- Serkan Menekşe (ORCID: https://orcid.org/0000-0002-2134-2128)
- Engin Kut (ORCID: https://orcid.org/0000-0002-5328-5607)
- Gülhan Özkanlı (ORCID: https://orcid.org/0000-0003-3912-7191)
- Elif Şahin (ORCID: https://orcid.org/0000-0002-1976-3951)
- Alper Yaşar (ORCID: https://orcid.org/0000-0001-8814-8947)
- Sena Ece Davarcı (ORCID: https://orcid.org/0000-0003-1142-9411)
- Funda Yılmaz (ORCID: https://orcid.org/0000-0002-7409-5730)
- Özlem Özdemir (ORCID: https://orcid.org/0000-0003-2520-5953)
- Deniz Can Güven (ORCID: https://orcid.org/0000-0002-6924-9467)
- Sibel Oyucu Orhan (ORCID: https://orcid.org/0000-0001-8217-3471)
- Nilgün Yıldırım (ORCID: https://orcid.org/0000-0001-8198-2605)
- Olçun Ümit Ünal (ORCID: https://orcid.org/0000-0001-7698-3574)
- Müge Karaoğlanoğlu
Institutions
- Sakarya University (TR)
- Çanakkale Onsekiz Mart Üniversitesi (TR)
- Van Yüzüncü Yıl Üniversitesi (TR)
- Tekirdağ Namık Kemal University (TR)
- Bursa Uludağ Üni̇versi̇tesi̇ (TR)
- Izmir University (TR)
- Anadolu University (TR)
- Koç University (TR)
- Selçuk University (TR)
- Fırat University (TR)
- Ankara University (TR)
- Recep Tayyip Erdoğan University (TR)
- Manisa Celal Bayar University (TR)
- Bilkent University (TR)
- Dokuz Eylül University (TR)
- State Hospital (GB)
- Acıbadem University (TR)
- Memorial Ankara Hospital (TR)
- Necmettin Erbakan University (TR)
- Nara City Hospital (JP)
- Suleyman Demirel University (KZ)
- City Hospital (GB)
- Sağlık Bilimleri Üniversitesi (TR)
- Universidad CES (CO)
- Ankara Yıldırım Beyazıt University (TR)
- Acıbadem Adana Hospital (TR)
- Afyonkarahisar Sağlık Bilimleri Üniversitesi
- University of Health Sciences (SO)
- Ankara Bilkent City Hospital (TR)
- Pamukkale University (TR)
- Istanbul Arel University (TR)
- Mersin Üniversitesi (TR)
- Kocaeli Üniversitesi (TR)
- Cukurova University (TR)
- Gaziantep University (TR)
- Ordu University (TR)
- Hacettepe University (TR)
- Istanbul University (TR)
- Marmara University (TR)
- University of Health Sciences Antigua (AG)
Publication Details
- Journal
- Turkish Journal of Clinics and Laboratory
- Published
- 2025-06-30
- DOI
- https://doi.org/10.18663/tjcl.1639022
- Citations
- 1
- Primary Topic
- Advanced Breast Cancer Therapies
- Type
- article
- Field-Weighted Citation Impact
- 1.52