Myocardium-to-cavity ratio derived from simultaneous 99mTc-PYP/201Tl dual-isotope SPECT imaging to differentially diagnose transthyretin cardiac amyloidosis
The M/C ratio demonstrated superior diagnostic accuracy compared to the H/CL ratio, particularly in eliminating false positive cases. Its simplicity and reproducibility make it a promising alternative for routine clinical practice, potentially replacing the H/CL ratio in dual-isotope imaging.
Authors
- Teppei Kitano
- Kenichi Nakajima (ORCID: https://orcid.org/0000-0001-7188-8746)
- Kunihiko Yokoyama
- Tatsuya Yoneyama
- Shozo Yamashita
- Haruki Yamamoto
- Hiromu Kato
Institutions
- Kanazawa University (JP)
- Public Central Hospital of Matto Ishikawa (JP)
Publication Details
- Journal
- EJNMMI Reports
- Published
- 2025-06-30
- DOI
- https://doi.org/10.1186/s41824-025-00255-7
- Primary Topic
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Hirosaki University
- Japan Society for the Promotion of Science
- Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province