An Extremely Rare Case of Coexisting Neuroendocrine Carcinoma and Tumor of the Whole Pancreas with Hepatoid Differentiation

We herein present an extremely rare case of coexisting NET and NEC of the whole pancreas with hepatoid differentiation. Due to a remarkable response to chemotherapy, conversion surgery was performed. However, early recurrence of liver metastases accompanied by a rapid increase in serum AFP levels occurred, and the prognosis was poor. Pancreatic HC should be considered when encountering a bulky tumor of the pancreas with elevated serum AFP levels, and further case series and analysis are needed to determine the appropriate treatment strategy.

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Publication Details

Journal
Surgical Case Reports
Published
2025-01-01
DOI
https://doi.org/10.70352/scrj.cr.24-0058
Primary Topic
Neuroendocrine Tumor Research Advances
Type
article
Field-Weighted Citation Impact
0.00

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article

An Extremely Rare Case of Coexisting Neuroendocrine Carcinoma and Tumor of the Whole Pancreas with Hepatoid Differentiation

Ippei Matsumoto, Chihoko Nobori, Atsushi Takebe, Yuta Yoshida et al.
Surgical Case Reports
Neuroendocrine Tumor Research Advances
article

An Extremely Rare Case of Coexisting Neuroendocrine Carcinoma and Tumor of the Whole Pancreas with Hepatoid Differentiation

Ippei Matsumoto, Chihoko Nobori, Atsushi Takebe, Yuta Yoshida, Takuya Nakai, Katsuya Ami, Takaaki Murase, Dongha Lee, Keiko Kamei, Takaaki Chikugo, Masaya Nakano
article en

Abstract

We herein present an extremely rare case of coexisting NET and NEC of the whole pancreas with hepatoid differentiation. Due to a remarkable response to chemotherapy, conversion surgery was performed. However, early recurrence of liver metastases accompanied by a rapid increase in serum AFP levels occurred, and the prognosis was poor. Pancreatic HC should be considered when encountering a bulky tumor of the pancreas with elevated serum AFP levels, and further case series and analysis are needed to determine the appropriate treatment strategy.

Surgical Case ReportsVol. 11(1)
Kindai University (JP)
Kindai University, Kanazawa University
Good health and well-being
Openalex Percentile: Top 78%
Neuroendocrine Tumor Research Advances
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An Extremely Rare Case of Coexisting Neuroendocrine Carcinoma and Tumor of the Whole Pancreas with Hepatoid Differentiation — Ippei Matsumoto, Chihoko Nobori, et al. · Surgical Case Reports (2025) | TGRS Research Map | TGRS