Favorable response to tirabrutinib of elderly patient with lymphoplasmacytic lymphoma/Waldenström macroglobulinemia who relapsed 10 years after initial treatment

Key Figure.Contrast-enhanced CT images of the chest before and 4 months after the start of tirabrutinib, showing size reduction of the right lung hilar tumor and mediastinal LNs (white arrows) with treatment.LN indicated by the yellow arrow was considered to correspond to station #4R LN targeted by EBUS-TBNA (Figure 2).The infiltrate in the right S7 segment also disappeared (blue arrows).Note that the superior vena cava, azygos vein, and pulmonary artery passing through the tumor were patent.