Genetic Disease Behind Obesity And Its Nutritional Treatment; Prader-Willi Syndrome

Obesity is a health problem that reduces the quality of life and is associated with many chronic diseases. There are many physiological, socio-cultural, psychological, and genetic causes of obesity. Prader-Willi Syndrome is the most common genetic disease associated with obesity. Prader-Willi Syndrome is characterized by severe anorexia in infancy and hyperphagia in childhood. Hyperphagia, which begins in childhood, is the basis of obesity in Prader-Willi Syndrome. Hyperphagia in Prader-Willi Syndrome occurs as a result of the imbalance in fasting-satiety metabolism. Due to the increased levels of the hormone ghrelin, a feeling of satiety cannot occur. The treatments applied for Prader-Willi Syndrome aim to prevent obesity. It is stated that the most effective treatment method is medical nutrition therapy. To prevent obesity in Prader-Willi Syndrome, it is necessary to continue nutritional therapy for life.