Relationship between Erectile Dysfunction and Asymmetric Dimethyl Arginine Levels in Patients with End-Stage Renal Disease

Introduction: Asymmetric dimethylarginine is a major inhibitor of nitric oxide synthesis. Erectile dysfunction and chronic kidney disease (CKD) are associated with elevated levels of asymmetric dimethylarginine. This study aimed to examine the effects of ADMA on erectile dysfunction in patients undergoing peritoneal hemodialysis. Methods: A total of 32 peritoneal, 32 hemodialysis patients, and 32 healthy male volunteers were included in the study. Serum asymmetric dimethylarginine levels were measured, and clinical and laboratory parameters were analyzed. The International Index of Erectile Function-5 was used to evaluate sexual function and the Pittsburgh Sleep Quality Index was used to evaluate sleep quality. Depressive symptoms were assessed using the Beck Depression Inventory Scale. Results: Asymmetric dimethylarginine levels differed significantly among the three groups (p