THE EFFECT OF COLLAGEN HYDROLYZATE ON WOUND HEALING IN THE CONDITIONS OF EXPERIMENTAL MODELING OF THE COURSE OF THE WOUND PROCESS IN RATS

Despite the existence of multiple trends toward chronic wounds treatment, certain misunderstandings regarding the regeneration of connective tissue determine the need to address this problem.The aim of the study was to determine the features of post-traumatic regeneration in experimental conditions of collagen hydrolysate complex applying.Materials and methods. In the rats of the main group (13 (43.3%)), hydrolyzate of collagen was applied to the treatment process, in the comparison group (17 (56.7%)), the regeneration processes took place without additional influence.Results. Significant differences in the formation of the microcirculatory system began to be observed from the 7th day. The differences in capillary density were statistically significant. The same situation in the density of newly formed capillaries on the 14th day of the experiment was detected. In addition, on the 28th day after the injury, the main group of animals demonstrated more expressed collagen formation and more mature connective tissue development. In contrast, the comparison group of animals showed developing granulation tissue with slower maturation and a significantly higher presence of residual inflammatory infiltrate. Newly formed nerve trunks were predominantly observed in the group of animals treated with collagen. Conclusions. The effectiveness of collagen hydrolyzate to improve post-traumatic regeneration processes was demonstrated in an experimental model of induced wound process.