ADVANCES IN REGENERATIVE MEDICINE IN THE TREATMENT OF PREMATURE OVARIAN FAILURE. LITERATURE REVIEW

Premature ovarian failure is a clinical syndrome that leads to the loss of ovarian activity before the age of 40. The aim of the work is to collect, analyze, and summarize recent data on the latest strategies to restore fertility in patients with premature ovarian failure, namely transfer or replacement of mitochondria, stem cell transplantation and exosome transplantation. Materials and methods. Analyzed scientific publications in the international electronic scientometric database PubMed by keywords: fertility, infertility, reproductive technologies, stem cells, oocytes. These keywords were combined with other search phrases relevant to the topic.Results. Our analysis and summary of recent data allows us to state the following 1) For the clinical application of the transfer orreplacement of mitochondria, further studies of the mitochondrial interaction as the main effect on the new organism after the replacementof mitochondria are needed, as well as, in particular, the establishment of an acceptable relationship between the mitochondrial DNA haplotypes of the donor and the patient. 2) Stem cell transplantation (into the ovary) is still an experimental treatment for premature ovarian failure. Stem cell transplantation as a potential therapeutic technology for premature ovarian failure requires further study. 3) Transplantation of exosomes is considered a therapeutic strategy for premature ovarian failure in the future.Conclusions: In general, the considered methods of regenerative medicine are the latest strategies to restore fertility in patients with premature ovarian failure.