CARBACETAM EFFECT ON OXIDATIVE STRESS MARKERS IN DIFFERENT GENDER RATS WITH METABOLIC SYNDROME

Introduction. Many factors are known to influence metabolic syndrome pathology. Meanwhile, certain scientific evidence indicates that oxidative stress with chronic inflammatory conditions is the base promoting the development of metabolic diseases.Objective of the research is to study carbacetam effect, as a GABA-receptor modulator, on pathogenic mechanisms of metabolic syndrome according to the oxidative stress markers of the hippocampus of different gender rats.Materials and methods. The experiments were conducted on non-linear laboratory albino male and female rats. To reproduce the metabolic syndrome model, the rats were kept on a high-fat diet enriched with the addition of solid pork lard and free access to fructose solution. Carbacetam was injected into the peritoneum in the dose of 5 mg/kg during 14 days. The state of oxidative stress was estimated by the parameters of the pro-oxidant-antioxidant system.Results. When carbacetam was administered, the activity of antioxidant protection enzymes was found to increase, and the content of products of lipid and protein peroxidation processes in the hippocampal neurons of rats of both genders with metabolic syndrome decreased.Conclusions. Carbacetam as a modulator of GABA-receptors in rats with metabolic syndrome decreases the content of products reacting with 2-thiobarbituric acid and the products of protein oxidation modification confirmed by histochemical method; increases the activity of antioxidant protection enzymes in rats of both genders with metabolic syndrome.