A Population Pharmacokinetic Model and Dosing Algorithm to Guide the Tacrolimus Starting and Follow-Up Dose in Living and Deceased Donor Kidney Transplant Recipients
In this international, multicenter study, age, CYP3A4 and CYP3A5 genotype, creatinine, height, and hematocrit were identified as significant covariates associated with tacrolimus pharmacokinetics, and can be used to predict the optimal individual's dose requirement for both living and deceased donor kidney transplant recipients.
Authors
- Dennis A. Hesselink (ORCID: https://orcid.org/0000-0003-1871-1962)
- Marith I. Francke (ORCID: https://orcid.org/0000-0001-5641-8375)
- Helena Colom (ORCID: https://orcid.org/0000-0002-7259-0199)
- Serge Moudio
- Laure Elens (ORCID: https://orcid.org/0000-0002-0039-3583)
- Dirk Jan A. R. Moes (ORCID: https://orcid.org/0000-0003-3219-253X)
- Brenda C. M. de Winter (ORCID: https://orcid.org/0000-0002-4452-8443)
- Aiko P. J. de Vries (ORCID: https://orcid.org/0000-0002-9284-3595)
- Sebastiaan D. T. Sassen (ORCID: https://orcid.org/0000-0002-4525-638X)
- Núria Lloberas (ORCID: https://orcid.org/0000-0002-3387-5757)
- Ron H. N. van Schaik
Institutions
- Leiden University Medical Center (NL)
- Erasmus MC (NL)
- Bellvitge University Hospital (ES)
- Institut d'Investigació Biomédica de Bellvitge (ES)
- Erasmus MC Cancer Institute (NL)
- Erasmus MC Transplant Institute
- Universitat de Barcelona (ES)
- UCLouvain (BE)
Publication Details
- Journal
- Clinical Pharmacokinetics
- Published
- 2025-06-30
- DOI
- https://doi.org/10.1007/s40262-025-01533-0
- Citations
- 3
- Primary Topic
- Renal Transplantation Outcomes and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 5.96