The OGT–TFF2 axis mediates intrahepatic crosstalk and MASH pathogenesis
These results identify an OGT-TFF2 axis that mediates the crosstalk between hepatocytes and CD4 T cells during MASH pathogenesis, revealing a potential therapeutic target for the treatment of chronic liver disease.
Authors
- Reina Desrouleaux (ORCID: https://orcid.org/0000-0002-3570-0125)
- Xiaoyong Yang (ORCID: https://orcid.org/0000-0003-4231-5062)
- Man Mohan Shrestha
- Laszlo Tibor Nagy (ORCID: https://orcid.org/0000-0001-6653-2155)
- Cuijuan Han (ORCID: https://orcid.org/0000-0002-7165-7785)
- Jiamei Le (ORCID: https://orcid.org/0000-0002-4776-1347)
- Yiheng Huang (ORCID: https://orcid.org/0009-0003-4722-3658)
- Lei Zhang (ORCID: https://orcid.org/0000-0001-5454-8758)
- Eric Wang (ORCID: https://orcid.org/0000-0001-7865-6702)
- Kelsey Berger
Institutions
- Johns Hopkins University (US)
- Yale Cancer Center (US)
- Yale University (US)
- Johns Hopkins All Children's Hospital (US)
- Jackson Laboratory (US)
Publication Details
- Journal
- Hepatology
- Published
- 2025-06-30
- DOI
- https://doi.org/10.1097/hep.0000000000001445
- Citations
- 2
- Primary Topic
- Helicobacter pylori-related gastroenterology studies
- Type
- article
- Field-Weighted Citation Impact
- 4.01