Cerebrospinal 14-3-3 Protein Levels as a Neuroaxonal Biomarker in Aquaporin-4 Antibody–Positive Neuromyelitis Optica Spectrum Disorder
This study provides Class IV evidence that in individuals presenting with acute myelitis, CSF 14-3-3 differentiates AQP4-NMOSD from MS or MOGAD with a sensitivity of 0.60 (0.30-0.80) and specificity of 0.95 (0.84-1.00).
Authors
- Ana Quiroga‐Varela (ORCID: https://orcid.org/0000-0003-1989-7113)
- Sara Llufriú (ORCID: https://orcid.org/0000-0003-4273-9121)
- Victòria Fernández (ORCID: https://orcid.org/0000-0002-4809-8196)
- Andreu Vilaseca (ORCID: https://orcid.org/0000-0001-8147-8505)
- Mireia Castillo (ORCID: https://orcid.org/0000-0001-8979-3219)
- Jan D. Lünemann (ORCID: https://orcid.org/0000-0002-3007-708X)
- Álvaro Cobo‐Calvo (ORCID: https://orcid.org/0000-0002-2574-0721)
- Xavier Montalbán (ORCID: https://orcid.org/0000-0002-0098-9918)
- Luca Bollo (ORCID: https://orcid.org/0000-0002-3673-2030)
- María Sepúlveda (ORCID: https://orcid.org/0000-0002-3078-645X)
- Mar Tintoré (ORCID: https://orcid.org/0000-0001-9999-5359)
- Gary Álvarez Bravo (ORCID: https://orcid.org/0000-0003-0342-0177)
- Alessandro Dinoto (ORCID: https://orcid.org/0000-0002-3249-4792)
- Adrián Valls Carbó (ORCID: https://orcid.org/0000-0002-4831-1276)
- Nicolás Fissolo (ORCID: https://orcid.org/0000-0002-7701-9346)
- Javier Villacieros‐Álvarez (ORCID: https://orcid.org/0000-0002-5443-1434)
- Albert Saiz (ORCID: https://orcid.org/0000-0002-5793-8791)
- Georgina Arrambide (ORCID: https://orcid.org/0000-0002-2657-5510)
- Sara Mariotto (ORCID: https://orcid.org/0000-0002-7806-3103)
- Carmen Espejo (ORCID: https://orcid.org/0000-0001-9949-5901)
- Thaís Armangué (ORCID: https://orcid.org/0000-0001-6192-6171)
- Lluís Ramió‐Torrentà (ORCID: https://orcid.org/0000-0002-6999-1004)
- Manuel Comabella (ORCID: https://orcid.org/0000-0002-2373-6657)
- Yolanda Blanco (ORCID: https://orcid.org/0000-0002-1834-0498)
- Lucía Gutiérrez (ORCID: https://orcid.org/0000-0001-7312-7254)
Institutions
- Universitat de Vic - Universitat Central de Catalunya (ES)
- University of Verona (IT)
- Universitat Autònoma de Barcelona (ES)
- Hospital Sant Joan de Déu Barcelona (ES)
- Universitat de Girona (ES)
- Instituto de Salud Carlos III (ES)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- Vall d'Hebron Institut de Recerca (ES)
- University Hospital Münster (DE)
- Institut d'Investigació Biomèdica de Girona (ES)
- Hospital Clínic de Barcelona (ES)
- Hospital Santa Caterina (ES)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- Neurology Neuroimmunology & Neuroinflammation
- Published
- 2025-06-30
- DOI
- https://doi.org/10.1212/nxi.0000000000200432
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00