The effects of long-term co-exposure to nanocarbon black particles and benzo[a]pyrene on ROS levels and the AKT/P27 signaling pathway in BEAS-2B cells
Long-term co-exposure to NCBP and B[a]P exacerbates oxidative damage in BEAS-2B cells by activating the AKT signaling pathway, suppressing P27 expression, and promoting ROS accumulation. This study elucidates potential mechanisms of multi-pollutant synergistic effects, providing new insights for health risk assessment of environmental co-exposure.
Authors
- Hong Liang (ORCID: https://orcid.org/0000-0002-0886-487X)
- Jiyuan Li (ORCID: https://orcid.org/0000-0002-4766-677X)
- Mingxia Wang (ORCID: https://orcid.org/0000-0002-5244-432X)
- Shuli Ma
- Linlin Du (ORCID: https://orcid.org/0000-0003-4625-5693)
- Weidong Zhang (ORCID: https://orcid.org/0000-0002-7384-2490)
- Feng Hu (ORCID: https://orcid.org/0000-0001-6325-8330)
- Lingxin Kong (ORCID: https://orcid.org/0000-0003-2253-8517)
- Jiping Li (ORCID: https://orcid.org/0000-0001-5719-5054)
- Xingsan Li
Institutions
- Qiqihar University (CN)
- Qiqihar Medical University (CN)
Publication Details
- Journal
- Medicine
- Published
- 2025-06-27
- DOI
- https://doi.org/10.1097/md.0000000000043016
- Primary Topic
- Air Quality and Health Impacts
- Type
- article
- Field-Weighted Citation Impact
- 0.00