The DCIS–IBC guide board on predicting postoperative upgrading in breast ductal carcinoma in situ: clinical insights from a multicenter study
The DCIS-IBC Guide Board is the first Asian-specific model integrating clinicopathological predictors to identify high-risk DCIS patients. It facilitates personalized decisions, such as omitting sentinel lymph node biopsy while reducing overtreatment. Although external validation showed moderate performance, this tool addresses critical population heterogeneity and enhances preoperative risk assessment. Prospective multicenter studies are warranted to optimize generalizability and explore multimodal predictors.
Authors
- Juan Du (ORCID: https://orcid.org/0000-0001-8190-3524)
- Yudong Zhou (ORCID: https://orcid.org/0000-0002-6364-3869)
- Miaomiao Niu (ORCID: https://orcid.org/0000-0001-6368-8525)
- Yi Pan (ORCID: https://orcid.org/0000-0003-4945-5631)
- Jianing Zhang
- Danni Li (ORCID: https://orcid.org/0000-0002-2293-7473)
- Bin Wang (ORCID: https://orcid.org/0000-0002-5474-1002)
- Dong Fan (ORCID: https://orcid.org/0000-0002-5182-9113)
- Lizhe Zhu (ORCID: https://orcid.org/0000-0002-5507-6323)
- Yu Ren (ORCID: https://orcid.org/0009-0009-4929-6221)
- Jiaqi Zhang (ORCID: https://orcid.org/0000-0002-7449-4176)
- Siyuan Jiang
- Chaorui Duan
Institutions
- Air Force Medical University (CN)
Publication Details
- Journal
- Breast Cancer Research and Treatment
- Published
- 2025-06-30
- DOI
- https://doi.org/10.1007/s10549-025-07763-x
- Primary Topic
- Breast Cancer Treatment Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Key Research and Development Projects of Shaanxi Province