Amyloid-Beta Pathology and Cognitive Performance in Centenarians
These results indicate that Aβ pathology is not a benign consequence of aging. Even in the oldest individuals, Aβ and tau pathology interaction was consistent with the amyloid cascade hypothesis.
Authors
- Marc Hulsman (ORCID: https://orcid.org/0000-0002-9889-3606)
- Susan K. Rohde (ORCID: https://orcid.org/0000-0002-9985-9645)
- Annemieke J.M. Rozemüller (ORCID: https://orcid.org/0000-0003-2528-4428)
- Linda M.C. Lorenz
- Philip Scheltens (ORCID: https://orcid.org/0000-0002-1046-6408)
- Jeroen J.M. Hoozemans (ORCID: https://orcid.org/0000-0002-2888-8967)
- Marieke Graat
- Henne Holstege (ORCID: https://orcid.org/0000-0002-7688-3087)
- Timothy E. Richardson (ORCID: https://orcid.org/0000-0001-7068-5517)
- Sietske A.M. Sikkes (ORCID: https://orcid.org/0000-0002-0161-3656)
- Dominique Daatselaar (ORCID: https://orcid.org/0000-0002-7963-2793)
- Jamie M. Walker (ORCID: https://orcid.org/0000-0003-1263-7394)
- Patricia Fierro‐Hernández
- Meng Zhang (ORCID: https://orcid.org/0000-0002-0766-6388)
- Maruelle C. Luimes
- Myke E. van der Hoorn
Institutions
- Netherlands Institute for Neuroscience (NL)
- Amsterdam Neuroscience (NL)
- Amsterdam University Medical Centers (NL)
- VIB-KU Leuven Center for Brain & Disease Research (BE)
- Vrije Universiteit Amsterdam (NL)
- Delft University of Technology (NL)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- JAMA Neurology
- Published
- 2025-06-30
- DOI
- https://doi.org/10.1001/jamaneurol.2025.1734
- Citations
- 5
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 7.36