B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response
Our results support ongoing clinical evaluation of B7-H3.CAR T cells for ependymomas and provide model systems for further studying determinants of anti-ependymoma CAR T-cell treatment efficacy and resistance.
Authors
- Peter Vogel (ORCID: https://orcid.org/0000-0002-7535-0545)
- Tram Dao (ORCID: https://orcid.org/0000-0002-8856-6548)
- Heather Sheppard (ORCID: https://orcid.org/0000-0002-9623-2812)
- Jason Chiang (ORCID: https://orcid.org/0000-0003-3623-8996)
- Michaela Meehl (ORCID: https://orcid.org/0000-0002-4652-0701)
- Deanna Langfitt (ORCID: https://orcid.org/0000-0003-0941-5360)
- Alisha Kardian (ORCID: https://orcid.org/0000-0002-7438-2107)
- Siri Ippagunta (ORCID: https://orcid.org/0000-0002-4714-8390)
- Diana Dinh (ORCID: https://orcid.org/0009-0004-5179-2412)
- Srinidhi Varadharajan (ORCID: https://orcid.org/0000-0002-2033-0758)
- Jorge Ibañez-Vega (ORCID: https://orcid.org/0000-0003-4317-8573)
- Wilda Orisme
- Meghan B. Ward (ORCID: https://orcid.org/0000-0002-1329-9713)
- Jeffrey Steinberg (ORCID: https://orcid.org/0000-0003-4110-3586)
- Stephen C. Mack (ORCID: https://orcid.org/0000-0001-9620-4742)
- David W. Ellison (ORCID: https://orcid.org/0000-0003-1239-7757)
- Sanya Mehta (ORCID: https://orcid.org/0009-0003-3730-9642)
- Shannon Lange (ORCID: https://orcid.org/0000-0003-3907-6072)
- Giedre Krenciute (ORCID: https://orcid.org/0000-0003-4335-0644)
- Amber B. Jones (ORCID: https://orcid.org/0000-0001-8808-4568)
- Erik Emanus
- Nic Laboe
Institutions
- St. Jude Children's Research Hospital (US)
- University of Tennessee Health Science Center (US)
- Baylor College of Medicine (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-06-30
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-3083
- Citations
- 4
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 4.18
Funders
- U.S. Department of Defense
- Assisi Foundation of Memphis
- Alex's Lemonade Stand Foundation for Childhood Cancer
- St. Jude Children's Research Hospital
- CERN
- American Lebanese Syrian Associated Charities
- National Cancer Institute