B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response

Our results support ongoing clinical evaluation of B7-H3.CAR T cells for ependymomas and provide model systems for further studying determinants of anti-ependymoma CAR T-cell treatment efficacy and resistance.

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Publication Details

Journal
Clinical Cancer Research
Published
2025-06-30
DOI
https://doi.org/10.1158/1078-0432.ccr-24-3083
Citations
4
Primary Topic
CAR-T cell therapy research
Type
article
Field-Weighted Citation Impact
4.18

Funders

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article

B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response

Peter Vogel, Tram Dao, Heather Sheppard, Jason Chiang et al.
4 citations
Clinical Cancer Research
CAR-T cell therapy research
4.18
article

B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response

Peter Vogel, Tram Dao, Heather Sheppard, Jason Chiang, Michaela Meehl, Deanna Langfitt, Alisha Kardian, Siri Ippagunta, Diana Dinh, Srinidhi Varadharajan, Jorge Ibañez-Vega, Wilda Orisme, Meghan B. Ward, Jeffrey Steinberg, Stephen C. Mack, David W. Ellison, Sanya Mehta, Shannon Lange, Giedre Krenciute, Amber B. Jones, Erik Emanus, Nic Laboe
article en
4 citations

Abstract

Our results support ongoing clinical evaluation of B7-H3.CAR T cells for ependymomas and provide model systems for further studying determinants of anti-ependymoma CAR T-cell treatment efficacy and resistance.

Clinical Cancer ResearchVol. 31(17)
St. Jude Children's Research Hospital (US), University of Tennessee Health Science Center (US), Baylor College of Medicine (US)
U.S. Department of Defense, Assisi Foundation of Memphis, Alex's Lemonade Stand Foundation for Childhood Cancer, St. Jude Children's Research Hospital, CERN, American Lebanese Syrian Associated Charities, National Cancer Institute
Good health and well-being
Openalex Percentile: Top 5%
CAR-T cell therapy research
4.18
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