Study on the Mechanism of Bone Marrow Stem Cell-Derived Exosome miR-30a/DLL4 Acting on Traumatic Brain Injury Angiogenesis

Bone marrow stem cell exosomes promote post-TBI angiogenesis and nerve function recovery, partially through the regulation of miR-30a-5p and DLL4 expression. These findings suggest that BMSC-derived exosomes may offer a novel therapeutic strategy for TBI and craniofacial trauma. For surgeons, this study provides a preclinical foundation for developing exosome-based intraoperative adjuvants to enhance vascularization in trauma sites, thereby improving graft survival in reconstructive surgery and reducing postoperative complications such as ischemia-reperfusion injury.