EphB2-mediated ephrin-B reverse signaling on microglia drives an anti-viral, but inflammatory and neurotoxic response associated with HIV
Our study suggests that elevated EphB2, and its reverse signaling through ephrin-B1 in microglia contribute to neuroinflammation and neurotoxicity in neuroHIV.
Authors
- Samantha N. Sutley-Koury (ORCID: https://orcid.org/0000-0001-9357-2259)
- Xinru Qiu (ORCID: https://orcid.org/0000-0003-1391-252X)
- Hina Singh (ORCID: https://orcid.org/0000-0001-7067-1991)
- Iryna M. Ethell (ORCID: https://orcid.org/0000-0002-1324-6611)
- Marcus Kaul (ORCID: https://orcid.org/0000-0003-3202-670X)
- Jeffrey Koury (ORCID: https://orcid.org/0000-0002-7368-4891)
- Ricky Maung
- D Fok
- Benjamin B. Gelman
Institutions
- University of California, Riverside (US)
- Sanford Burnham Prebys Medical Discovery Institute (US)
- Discovery Institute (US)
- The University of Texas Medical Branch at Galveston (US)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2025-06-30
- DOI
- https://doi.org/10.1186/s12974-025-03481-9
- Citations
- 2
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.68
Funders
- National Institutes of Health
- University of California, San Diego
- National Institute of Neurological Disorders and Stroke