Dental biofilm serves as an ecological reservoir of acidogenic pathobionts in head and neck cancer patients with radiotherapy-related caries
This study focuses on a dedicated collection of diverse oral sites to comprehensively investigate microbial differences between patients who develop RRC and those who do not. RRC is a severe oral disease that profoundly impacts on the oral health and overall quality of life of cancer survivors. Leveraging shotgun metagenomics, we characterize the unique microbial variations in <i>in vivo</i> irradiated dental biofilms, unveiling novel insights into the microbial ecology of radiotherapy-treated patients. Furthermore, this research integrates extensive data on oral health and oncological profiles, providing a comprehensive understanding of the intricate relationship between oral microbial communities and the outcomes of radiotherapy-induced toxicity.
Authors
- Wanessa Miranda‐Silva (ORCID: https://orcid.org/0000-0002-5666-8689)
- Júlia S. Bruno (ORCID: https://orcid.org/0000-0002-3152-3432)
- Franciele Hinterholz Knebel (ORCID: https://orcid.org/0000-0001-8275-9499)
- Eduardo Rodrigues Fregnani (ORCID: https://orcid.org/0000-0001-5196-7631)
- Anamaria A. Camargo (ORCID: https://orcid.org/0000-0002-6076-9597)
- Lilian T. Inoue (ORCID: https://orcid.org/0009-0003-9484-1491)
- Vitor Heidrich (ORCID: https://orcid.org/0000-0001-6617-9187)
- Paula Fontes Asprino (ORCID: https://orcid.org/0000-0002-2157-5853)
- Tatiana M. M. T. Alves
- Felipe Cicci Farinha Restini (ORCID: https://orcid.org/0000-0002-5849-2218)
- Elisangela Monteiro Coser
Institutions
- University of Trento (IT)
- Hospital Sírio-Libanês (BR)
- Molecular Oncology (United States) (US)
Publication Details
- Journal
- mSphere
- Published
- 2025-06-30
- DOI
- https://doi.org/10.1128/msphere.00257-25
- Primary Topic
- Oral health in cancer treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00