Metabolomic profiling of a dementia cohort in Egypt: a step towards a neuro-exposome model
Abstract Dementia poses a significant global health challenge, with increasing impact on individuals and healthcare systems. This study aims to investigate the metabolic profiles of clinical Alzheimer’s disease (AD) and vascular dementia (VaD) patients in Egypt, seeking to identify connections between metabolic disruptions and environmental factors. Utilizing serum samples from 61 AD patients and 76 VaD patients compared to 100 healthy controls, the research employed untargeted LC-MS and generalized regression analysis. The findings revealed significant alterations in 59 metabolites in AD patients and 69 in VaD patients, including environmental contaminants. Additionally, pathway enrichment analysis indicated distinct metabolic pathways affected in each group, such as amino acid metabolism in AD and purine metabolism in VaD. This research provides insights into the biological pathways and environmental agents linked to dementia, highlighting the need for diverse populations in metabolomic studies to improve prevention and intervention strategies globally.
Authors
- A. Mohamed (ORCID: https://orcid.org/0000-0003-0873-5194)
- Shimaa Adel Heikal (ORCID: https://orcid.org/0000-0002-0798-1863)
- Atef El‐Taher (ORCID: https://orcid.org/0000-0003-0188-420X)
- Amna Ibrahim
- Gharib Fawi
- H. Ibrahim (ORCID: https://orcid.org/0000-0001-9607-9443)
- Sara Elfarrash (ORCID: https://orcid.org/0000-0002-4573-3131)
- Samer Salama (ORCID: https://orcid.org/0000-0001-9510-0343)
- Nesma G. Elsheikh (ORCID: https://orcid.org/0000-0003-0803-171X)
- Mohamed Salama (ORCID: https://orcid.org/0000-0002-0002-9108)
- Noha Abo Elftoh
- Samir Shamma (ORCID: https://orcid.org/0000-0003-3508-1130)
- Mostafa Saber
- Eman Ali (ORCID: https://orcid.org/0000-0002-5771-8166)
- Mohamad Rosni Othman (ORCID: https://orcid.org/0000-0001-8838-0033)
- Eman G. Khedr (ORCID: https://orcid.org/0000-0003-2968-7494)
- Noha A. Yousri (ORCID: https://orcid.org/0000-0003-1918-0331)
- Ahmed Shoyb
- Heba M. Tawfik (ORCID: https://orcid.org/0000-0001-5688-961X)
- Esraa Ali
- Shady M. Safwat
- Ayman A. Saeed
- Ahmed Qayaty
- Muhammad Abdelshafi
Institutions
- Ain Shams University (EG)
- Beni-Suef University (EG)
- Mansoura University (EG)
- Trinity College Dublin (IE)
- Mansoura University Hospital (EG)
- National Water Research Center (EG)
- Children Cancer Hospital (EG)
- American University in Cairo (EG)
- Alexandria University (EG)
- Aswan University (EG)
- Assiut University (EG)
- Sohag University (EG)
Publication Details
- Journal
- npj Dementia
- Published
- 2025-06-30
- DOI
- https://doi.org/10.1038/s44400-025-00021-3
- Primary Topic
- Health, Environment, Cognitive Aging
- Type
- article
- Field-Weighted Citation Impact
- 0.00