<scp>CircMAN1A2</scp> Levels Determine <scp>GBM</scp> Susceptibility to <scp>TMZ</scp> in a Pathway Involving <scp>TEP1‐</scp> and <scp>KEAP1</scp>‐Mediated <scp>NRF2</scp> Degradation Leading to Ferroptosis
CircMAN1A2 suppresses GBM progression and TMZ resistance by inducing ferroptosis and modulating the TEP1-KEAP1-NRF2-ANXA1 axis. It represents a potential therapeutic target in GBM.
Authors
- Wei Zheng (ORCID: https://orcid.org/0000-0003-1034-0757)
- Hao Chi (ORCID: https://orcid.org/0000-0002-5210-0770)
- Jinpeng Hu
- Zhitao Jing (ORCID: https://orcid.org/0000-0002-8915-9039)
- Hao Li (ORCID: https://orcid.org/0000-0003-0513-0771)
- Zhigang Fan (ORCID: https://orcid.org/0000-0002-1190-0894)
- Yongfeng Wang (ORCID: https://orcid.org/0000-0002-3476-6552)
- Xinqiao Li (ORCID: https://orcid.org/0009-0002-0179-9072)
Institutions
- Army Medical University (CN)
- Southwest Medical University (CN)
- Zhengzhou University (CN)
- Xinqiao Hospital (CN)
- First Hospital of China Medical University (CN)
- Henan Provincial Chest Hospital (CN)
- China Medical University (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2025-06-30
- DOI
- https://doi.org/10.1111/cns.70489
- Citations
- 3
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- National Natural Science Foundation of China
- Department of Science and Technology of Liaoning Province