Visible-Light-Promoted Copper-Catalyzed Etherification of Aryl Bromides via Energy Transfer
A visible-light-promoted copper-catalyzed C-O coupling reaction of alcohols with aryl bromides using eosin Y as the photosensitizer has been developed, in which energy transfer (EnT) from eosin Y to the copper complex of the oxalamide ligand generates an excited-state copper complex that facilitates oxidative addition of aryl bromides. This mild method enables the efficient synthesis of alkyl aryl ethers and biaryl ethers with a broad substrate scope and excellent tolerance of sensitive functional groups at room temperature.
Authors
- Jia Zheng (ORCID: https://orcid.org/0000-0003-2700-6413)
- W. L. Zhong (ORCID: https://orcid.org/0000-0003-1266-3808)
- Ruihua Cheng (ORCID: https://orcid.org/0000-0002-1171-2308)
- Qinghua Zhong (ORCID: https://orcid.org/0000-0001-6199-5599)
- Jinxing Ye (ORCID: https://orcid.org/0000-0003-3319-6807)
- Yueyue Ma (ORCID: https://orcid.org/0000-0001-8837-7117)
- Xin Yang (ORCID: https://orcid.org/0000-0003-1041-0030)
- Xiantong Yao
- Dali Yang (ORCID: https://orcid.org/0000-0002-8589-1003)
- Zhengjie Wang (ORCID: https://orcid.org/0000-0002-8227-881X)
- Rui-yuan Peng
Institutions
- Guangdong University of Technology (CN)
- East China University of Science and Technology (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-06-30
- DOI
- https://doi.org/10.1021/acs.orglett.5c01919
- Citations
- 3
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 2.81
Funders
- National Natural Science Foundation of China