L-Phenylalanine promotes liver steatosis by inhibiting BNIP3-mediated mitophagy
Our study revealed the role of L-Phe in regulating lipid metabolism and promoting liver steatosis via BNIP3-mediated mitophagy. These findings provide novel insights into the link between L-Phe and liver steatosis, suggesting potential nutritional intervention strategies for preventing MASLD.
Authors
- Kun Zhang (ORCID: https://orcid.org/0009-0001-5137-987X)
- Yuefeng Yu (ORCID: https://orcid.org/0000-0001-7439-4231)
- Bowei Yu (ORCID: https://orcid.org/0009-0001-7056-400X)
- Lingli Cai
- Ningjian Wang (ORCID: https://orcid.org/0000-0001-9591-6991)
- Chi Chen (ORCID: https://orcid.org/0000-0001-8277-0268)
- Haojie Zhang (ORCID: https://orcid.org/0000-0002-4577-3600)
- Li Jiang (ORCID: https://orcid.org/0000-0002-1622-2623)
- Fangzhen Xia (ORCID: https://orcid.org/0000-0002-1069-0418)
- Ziteng Zhang (ORCID: https://orcid.org/0009-0001-0851-0502)
- Xiaoqin Xu
- Ying Sun (ORCID: https://orcid.org/0009-0008-5636-4350)
- Yingli Lu
Institutions
- Shanghai Jiao Tong University (CN)
- Shanghai Ninth People's Hospital (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Shuguang Hospital (CN)
- Cochrane (GB)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-06-30
- DOI
- https://doi.org/10.1186/s10020-025-01303-5
- Citations
- 4
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 5.42
Funders
- National Natural Science Foundation of China
- Shanghai Municipal Human Resources and Social Security Bureau