Integrated Analysis of Serum and Fecal Metabolites Reveals the Role of Bile Acid Metabolism in Drug-induced Liver Injury: Implications for Diagnostic and Prognostic Biomarkers
The integrated analysis of serum and fecal metabolites uncovers the significant disruption of bile acid metabolites as a key contributing factor in the pathogenesis of DILI. Our study offers promising potential biomarkers for the diagnosis and prognosis of DILI, paving the way for a novel perspective in the realm of DILI diagnosis and treatment.
Authors
- Haocheng Zheng (ORCID: https://orcid.org/0000-0001-9858-4451)
- Sici Wang (ORCID: https://orcid.org/0000-0003-1643-4076)
- Xia Ding (ORCID: https://orcid.org/0000-0002-7346-942X)
- Simiao Yu (ORCID: https://orcid.org/0000-0002-1755-1496)
- Li P (ORCID: https://orcid.org/0000-0003-2896-9190)
- Jing Jing (ORCID: https://orcid.org/0000-0001-9822-5758)
- Tingting He (ORCID: https://orcid.org/0000-0002-6127-852X)
- Ruilin Wang (ORCID: https://orcid.org/0000-0003-4459-4659)
Institutions
- Beijing University of Chinese Medicine (CN)
- Chinese PLA General Hospital (CN)
Publication Details
- Journal
- Journal of Clinical and Translational Hepatology
- Published
- 2025-06-30
- DOI
- https://doi.org/10.14218/jcth.2025.00073
- Citations
- 1
- Primary Topic
- Drug-Induced Hepatotoxicity and Protection
- Type
- article
- Field-Weighted Citation Impact
- 1.56
Funders
- National Natural Science Foundation of China