Immunohistochemical expression of SOX2 and OCT4 in primary odontogenic keratocyst, recurrent odontogenic keratocyst, and odontogenic keratocyst treated by the decompression technique
High expression of SOX2 in OKCs supports its role as a marker of epithelial stemness and a potential biomarker for aggressive behaviour and recurrence. Limited expression of OCT4 suggests a minimal role in OKC pathobiology, possibly associated with early differentiation. Lack of OCT4 expression in decompressed lesions raises questions about the molecular efficacy of decompression therapy.
Authors
- Ravikanth Manyam (ORCID: https://orcid.org/0000-0001-6952-5014)
- Naga Supriya Alapati (ORCID: https://orcid.org/0000-0002-7119-2527)
- Neelam Kumar (ORCID: https://orcid.org/0000-0002-4346-2112)
- Puvvada Divya (ORCID: https://orcid.org/0000-0001-5945-9412)
- P Swetha (ORCID: https://orcid.org/0009-0002-2527-7121)
- Chinmayee Mannava
Institutions
- MNR Dental College and Hospital (IN)
- Vishnu Dental College
Publication Details
- Journal
- Journal of Oral and Maxillofacial Pathology
- Published
- 2025-04-01
- DOI
- https://doi.org/10.4103/jomfp.jomfp_254_24
- Citations
- 1
- Primary Topic
- Oral and Maxillofacial Pathology
- Type
- article
- Field-Weighted Citation Impact
- 1.79