Cervical Spinal Cord Magnetization Transfer Ratio and Its Relationship With Clinical Outcomes in Multiple Sclerosis
In this large sample of RIS and MS, cSC MTR was lowest in PPMS, with associations between MTR and clinical outcomes in MS but not RIS. These findings suggest that MTR provides important information about the underlying tissue microstructural integrity of the cSC relevant to clinical disability in established MS.
Authors
- Penelope Smyth (ORCID: https://orcid.org/0000-0003-1174-4577)
- Nathalie Arbour (ORCID: https://orcid.org/0000-0002-3718-1584)
- Anthony Feinstein (ORCID: https://orcid.org/0000-0002-0132-0909)
- Julien Cohen‐Adad (ORCID: https://orcid.org/0000-0003-3662-9532)
- Simon J. Graham (ORCID: https://orcid.org/0000-0002-9647-6569)
- Akash Chopra
- Shannon Kolind (ORCID: https://orcid.org/0000-0003-1362-1968)
- Scott B. Patten (ORCID: https://orcid.org/0000-0001-9871-4041)
- Neda Rashidi‐Ranjbar (ORCID: https://orcid.org/0000-0002-2125-1090)
- Anthony Traboulsee (ORCID: https://orcid.org/0000-0002-0351-9639)
- Irene M. Vavasour (ORCID: https://orcid.org/0000-0001-9286-0953)
- Nathan W. Churchill (ORCID: https://orcid.org/0000-0001-8481-2505)
- Tom A. Schweizer (ORCID: https://orcid.org/0000-0003-2278-3539)
- Katherine Sawicka (ORCID: https://orcid.org/0000-0003-1771-1944)
- Melanie Guenette (ORCID: https://orcid.org/0000-0001-7112-704X)
- Lisa Eunyoung Lee (ORCID: https://orcid.org/0000-0002-8334-3740)
- Mojgan Hodaie (ORCID: https://orcid.org/0000-0001-6278-4929)
- Alexandre Prat (ORCID: https://orcid.org/0000-0001-6188-0580)
- Fabrizio Giuliani
- Larry D. Lynd (ORCID: https://orcid.org/0000-0002-7622-3919)
- Roger C. Tam (ORCID: https://orcid.org/0000-0002-4593-2587)
- Alice Schabas (ORCID: https://orcid.org/0000-0002-5925-1715)
- Pierre‐Louis Benveniste (ORCID: https://orcid.org/0009-0003-3122-1957)
- Yunyan Zhang (ORCID: https://orcid.org/0000-0001-7440-5420)
- Jiwon Oh
- Adelia Adelia
Institutions
- St. Michael's Hospital (CA)
- Providence Health Care (CA)
- University of British Columbia (CA)
- University of Alberta (CA)
- University of Calgary (CA)
- University of Toronto (CA)
- Public Health Ontario (CA)
- Women and Children’s Health Research Institute (CA)
- Centre Hospitalier de l’Université de Montréal (CA)
- Institute for Clinical Evaluative Sciences (CA)
- Mila - Quebec Artificial Intelligence Institute (CA)
- Unity Health Toronto
- Polytechnique Montréal (CA)
- Toronto Metropolitan University (CA)
Publication Details
- Journal
- Annals of Clinical and Translational Neurology
- Published
- 2025-06-29
- DOI
- https://doi.org/10.1002/acn3.70113
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Eli Lilly and Company
- Pfizer
- Sanofi
- Biogen
- F. Hoffmann-La Roche
- Johns Hopkins University
- Fondation Brain Canada
- Government of Alberta
- St. Michael's Hospital Foundation
- Multiple Sclerosis Society of Canada
- University of Cambridge
- University of Toronto
- National Institutes of Health
- EMD Serono
- Pfizer Canada