Calcifilaxis en paciente con enfermedad renal crónica, reporte de caso y revisión de la literatura

Calciphylaxis, a rare syndrome that causes skin necrosis, mainly affects patients undergoing hemodialysis; the annual incidence rate is 0.04% to 4%, and the mortality rate is 60% to 80%. The pathogenesis is multifactorial; it depends on the factors that cause calcification, such as alteration of calcium metabolism, phosphorus, hyperparathyroidism, female sex, diabetes, obesity; from the clinical point of view, calciphylaxis can progress from a painful purpura to extensive skin necrosis, causing death from sepsis. Treatment is based on wound care and elimination of the factors. Thus, a clinical case is presented of a 64-year-old woman with a history of chronic kidney disease, diabetes, criteria for urgent dialysis, presence of skin lesions on the lower limbs, with suspicion of calciphylaxis, confirmed by anatomopathology, presenting an unfavorable evolution, with an increase in the size of the skin lesions, poor prognosis and mortality.