PALB2 deficiency may sensitize H3K27M-mutant pediatric HGG cells to BMN673/talazoparib
Overall, our results may provide some reference value for further study of the effects of BMN673 and PALB2 deficiency in the treatment of H3K27M-mutant pHGG.
Authors
- Xiaolan Mo (ORCID: https://orcid.org/0000-0003-3623-3474)
- Houliang Deng (ORCID: https://orcid.org/0000-0002-7217-0063)
- Xiaowen Guan
- Xinke Xu
Institutions
- Zhengzhou University (CN)
- Guangzhou Women and Children Medical Center (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-06-30
- DOI
- https://doi.org/10.3389/fonc.2025.1589396
- Primary Topic
- PARP inhibition in cancer therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Washington
- Dana-Farber Cancer Institute
- National Natural Science Foundation of China
- Universidade de Macau
- Guangzhou Municipal Science and Technology Project