Patient-derived gastric cancer organoids model heterogeneity and stroma-mediated chemoresistance in poorly cohesive carcinoma
Patient-derived GC organoids especially PCC subtypes reliably recapitulate the complexity of solid-tumors heterogeneity, predict drug responses, and elucidate stromal contributions to therapy resistance. This model could be used to develop tailoring treatments and improve personalization of therapy for clinical management of PCC.
Authors
- Jin‐Yong Zhou (ORCID: https://orcid.org/0000-0003-4020-2187)
- Shuhong Zeng (ORCID: https://orcid.org/0000-0001-5548-790X)
- Rui Qiang
- Weixing Shen (ORCID: https://orcid.org/0000-0002-6454-3296)
- Hui Zhang (ORCID: https://orcid.org/0000-0001-6825-5649)
- Jun Qian (ORCID: https://orcid.org/0000-0002-8105-1306)
- Ke Fei (ORCID: https://orcid.org/0000-0003-0982-9256)
- Yuwen Zhuang (ORCID: https://orcid.org/0000-0002-7869-5522)
- Shuangshuang Wang (ORCID: https://orcid.org/0000-0001-9726-6742)
- Shenlin Liu (ORCID: https://orcid.org/0000-0001-9959-3704)
- Yi Hui Yin
Institutions
- Nanjing University of Chinese Medicine (CN)
- Jiangsu Province Hospital (CN)
Publication Details
- Journal
- Frontiers in Molecular Biosciences
- Published
- 2025-06-30
- DOI
- https://doi.org/10.3389/fmolb.2025.1631168
- Citations
- 4
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 4.18
Funders
- National Natural Science Foundation of China