FORMULATION AND EVALUATION OF ESOMEPRAZOLE MAGNESIUM TRIHYDRATE DELAYED RELEASE TABLETS

Esomeprazole is a inhibitor of proton pump (PPI) medication used for the managing of gastroesophageal reflux disease (GERD), protection of gastric to arrest regularity of ulcers in the stomach or gastric membrane damage from persistant use of NSAIDs, and for the medication of pathological higher secretory conditions including Zollinger-Ellison (ZE) Syndrome.The strategy of such system explains the release of medicament at a point in the GIT & denotes that the drug is not released instantly but, is being released eventually.Therefore, the formulation is designed in order to increase the stability of drug and optimizing the effect of a medicament by controlling drug release in the body in the lower gastrointestinal tract part.The Present project is to design and evaluate of Esomeprazole Mg trihydrate delayed released tablets using enteric coating.Various tablets are manufactured and proper formulation has selected for enteric coating procedure.Tablet coating was done, fulfil 3% increase in weight.Coating was done by using various polymers like hydroxyl propyl methyl cellulose phthalate to fulfil 5% weight gain.Disintegration test observed, formulations failed in 0.1 N HCl solution.So, the amount of enteric coating was raised to 8% w/w.In vitro evaluation of the manufactured tablets was carried out.Evaluation tests were done for tablets and show the result as good quality and as desirable as per enteric coated tablets appearance.