Stool-Based Molecular Tuberculosis Treatment Monitoring: A Faster Means for Detecting Persistent Mycobacteria Compared to Phenotypic Culture
Stool-based TB treatment monitoring correlates with sputum culture but provides results faster, leverages a more accessible specimen, and identifies patients with TB who are at risk for drug resistance and persistent 2-month culture positivity. None of the quantitative tests of bacillary burden singularly could predict symptom resolution or death.
Authors
- Rojelio Mejía (ORCID: https://orcid.org/0000-0003-4134-4558)
- H. Lester Kirchner (ORCID: https://orcid.org/0000-0002-2557-6749)
- Edson Mambuque (ORCID: https://orcid.org/0000-0002-9106-1444)
- Alexander Kay (ORCID: https://orcid.org/0000-0001-5283-4697)
- Shilzia Munguambe (ORCID: https://orcid.org/0000-0002-5433-727X)
- Anna M. Mandalakas (ORCID: https://orcid.org/0000-0002-8091-3509)
- Clement Gascua Adu-Gyamfi (ORCID: https://orcid.org/0000-0002-3190-9343)
- Tara Ness (ORCID: https://orcid.org/0000-0002-4425-418X)
- Gugu Maphalala (ORCID: https://orcid.org/0000-0002-3635-8405)
- Christoph Lange (ORCID: https://orcid.org/0000-0002-9691-4741)
- Lucía Carratalá-Castro (ORCID: https://orcid.org/0000-0003-2355-6477)
- Bariki Mtafya (ORCID: https://orcid.org/0000-0003-3772-8671)
- Alberto L. García‐Basteiro (ORCID: https://orcid.org/0000-0002-2038-5505)
- Sozinho Acácio (ORCID: https://orcid.org/0000-0002-3173-6446)
- Joanna Ehrlich (ORCID: https://orcid.org/0000-0001-7828-7222)
- Andrew R. DiNardo (ORCID: https://orcid.org/0000-0001-5990-6470)
- Durbbin Mulengwa (ORCID: https://orcid.org/0000-0003-0536-7859)
- Anca Vasiliù (ORCID: https://orcid.org/0000-0001-5336-7859)
- Nontobeko Maphalala (ORCID: https://orcid.org/0000-0001-9097-4631)
- Mangaliso Ziyane
- Abigail Seeger (ORCID: https://orcid.org/0009-0004-0149-6084)
- Belen Saaedra
Institutions
- Baylor College of Medicine (US)
- University of the Witwatersrand (ZA)
- Mbeya University of Science and Technology (TZ)
- Baylor College of Medicine Children’s Foundation (UG)
- Centro de Investigación Biomédica en Red (ES)
- German Center for Infection Research (DE)
- Manhiça Health Research Centre (MZ)
- Research Center Borstel - Leibniz Lung Center (DE)
- Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (ES)
- National Institute for Occupational Health (ZA)
- Barcelona Institute for Global Health (ES)
- Ministry of Health (SZ)
- National Institute for Medical Research (TZ)
- Geisinger Health System (US)
- Universitat de Barcelona (ES)
- University of Lübeck (DE)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2025-06-24
- DOI
- https://doi.org/10.1093/ofid/ofaf345
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- Fogarty International Center