Novel amide derivatives of pyrimidine piperidine; Design, synthesis and In-vitro anti-tubercular activity

Tuberculosis (TB) caused by M. tuberculosis, continues?to be a global threat, with the growing emergence of multidrug-resistant strains. A novel class of amide derivatives of?pyrimidine piperidine were designed. Molecular docking studies was performed through Schrodinger software against protein receptor (PDB ID-7F72) using Ethionamide as reference drug. Docking study represented that the SB-7, SB-14 and SB-15 had the maximum binding affinities i.e., -6.292, -6.443 and -7.556 respectively, to the protein receptor and considered as promising candidates for further synthesis. The synthesized compounds were characterized by Infra-red, NMR and Mass spectrometry and them in-vitro antimycobacterial activity was tested by Microplate Alamar Blue Assay (MABA) method. The minimum inhibitory concentration was?found significant for some derivatives, SB-7: 6.25 µg/ml and SB-14: 3.12 µg/ml, while it was more significant with SB-15 (1.6 µg/ml) against M. tuberculosis H37Rv strain, indicating their potential as promising antimycobacterial agent.