Catalytic Diastereoselective Synthesis of Bicyclo[3.2.1]octanediones
The bicyclo[3.2.1]octanone and bicyclo[3.2.1]octanedione scaffolds, along with their derivatives, are ubiquitous in natural products and synthetic pharmaceuticals. However, the synthetic routes to access these scaffolds have been relatively underdeveloped. Herein, this study introduces a unique reaction between pent‐4‐ene‐1,3‐diones and vinyl diketones, which serves as a versatile platform for the efficient synthesis of a wide array of bicyclo[3.2.1]octanediones in good to excellent yields. Furthermore, this study method facilitates diverse downstream transformations of these products, underscoring the versatility and potential of diketone‐based chemistry in constructing complex molecules.
Authors
- Shouang Lan
- Xinqiang Fang (ORCID: https://orcid.org/0000-0001-8217-7106)
- Lili Zhao (ORCID: https://orcid.org/0000-0003-2580-6919)
- Wennan Dong
- Chao Xu
- S. L. Yang (ORCID: https://orcid.org/0009-0001-6415-2404)
- Liyuan Zhou
- Chunyun Jiang
- Qinqin Cui
- Bao‐Tian Luo
- Xiangwen Kong (ORCID: https://orcid.org/0009-0008-0499-9102)
- Caiyi Ren
Institutions
- Fujian Normal University (CN)
- Fujian Institute of Research on the Structure of Matter (CN)
- Jining University (CN)
- Pingxiang University (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Advanced Synthesis & Catalysis
- Published
- 2025-06-16
- DOI
- https://doi.org/10.1002/adsc.202500324
- Primary Topic
- Axial and Atropisomeric Chirality Synthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- Natural Science Foundation of Fujian Province
- Natural Science Foundation of Shandong Province