Understanding Interactions Between Life Satisfaction and Genetic Predisposition on Risk of Alzheimer's Disease up to 14 Years Later: Findings From the UK Biobank
Results show that genetic risk for AD modified the relationship between life satisfaction and the risk of AD. This suggests that genetic risk may weaken associations between life satisfaction and AD risk. The findings clarify the mixed results of previous research on this topic and may contribute to more tailored approaches to the prevention of AD in the future.
Authors
- Darya Gaysina (ORCID: https://orcid.org/0000-0002-9283-5667)
- Natalie L. Marchant (ORCID: https://orcid.org/0000-0003-0669-6910)
- Roopal Desai (ORCID: https://orcid.org/0000-0003-4221-1546)
- Amber John (ORCID: https://orcid.org/0000-0002-8207-7698)
- Emily C Willroth (ORCID: https://orcid.org/0000-0002-4780-6883)
- Marcus Richards (ORCID: https://orcid.org/0000-0001-9191-2192)
- David Bartrés‐Faz (ORCID: https://orcid.org/0000-0001-6020-4118)
- Rob Saunders (ORCID: https://orcid.org/0000-0002-7077-8729)
- Aida Suárez González
- Joshua Stott (ORCID: https://orcid.org/0000-0003-1361-053X)
- Dorina Cadar
Institutions
- Brighton and Sussex Medical School (GB)
- University of Liverpool (GB)
- University of Sussex (GB)
- Washington University in St. Louis (US)
- UK Dementia Research Institute (GB)
- MRC Unit for Lifelong Health and Ageing (GB)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- University College London (GB)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- International Journal of Geriatric Psychiatry
- Published
- 2025-06-29
- DOI
- https://doi.org/10.1002/gps.70120
- Primary Topic
- Aging and Gerontology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Alzheimer's Society
- Alzheimer Society
- Alzheimer’s Research UK
- Institució Catalana de Recerca i Estudis Avançats
- Medical Research Council
- Economic and Social Research Council
- Agencia Estatal de Investigación
- National Institute on Aging