Effect of Clostridium butyricum and antibiotics using simultaneous simple suspension in mice with Clostridioides difficile infection
This study using mice demonstrates the effectiveness of simultaneous simple suspensions of CBM and antibiotics in treating CDI. This approach significantly reduces C. difficile counts, modulates cytokine levels, and maintains probiotic viability, potentially making it a viable option for administration via gastric tubes in clinical settings.
Authors
- Takuya Iwamoto (ORCID: https://orcid.org/0000-0002-6445-4410)
- Mao Hagihara
- Hideo Kato (ORCID: https://orcid.org/0000-0002-5272-9560)
- Chihiro Shiraishi (ORCID: https://orcid.org/0000-0002-1190-6540)
- Yuki Asai (ORCID: https://orcid.org/0000-0002-1933-8592)
- Hiroshige Mikamo (ORCID: https://orcid.org/0000-0001-8876-6411)
Institutions
- Aichi Medical University (JP)
- Mie University Hospital (JP)
Publication Details
- Journal
- Experimental and Molecular Pathology
- Published
- 2025-06-29
- DOI
- https://doi.org/10.1016/j.yexmp.2025.104979
- Primary Topic
- Clostridium difficile and Clostridium perfringens research
- Type
- article
- Field-Weighted Citation Impact
- 0.00