TBCancer: A database for exploring characteristics and functions of tissue‐biased genes in cancer
This study defined 10,921 tissue-biased genes across 54 normal tissues and 41 cancer types. Tumor-associated tissue-biased genes exhibit downregulation, mutations, and epigenetic modifications, correlating with poor clinical outcomes. Their inactivation promotes tumorigenesis by enhancing stemness and immune evasion, highlighting their value as prognostic biomarkers and therapeutic targets. To facilitate research, we developed a database integrating multi-omics data on these genes for mechanistic and therapeutic exploration.
Authors
- Zhuobin Lin (ORCID: https://orcid.org/0000-0002-6076-5879)
- Kunhua Hu (ORCID: https://orcid.org/0000-0001-9422-7828)
- Zhixiang Zuo (ORCID: https://orcid.org/0000-0002-2492-2689)
- Wei Liu (ORCID: https://orcid.org/0000-0002-5908-0661)
- Hongyan Sun
- Zhihang Chen (ORCID: https://orcid.org/0000-0002-6641-6426)
- Lin Tang (ORCID: https://orcid.org/0000-0002-2068-3123)
- Xiaoqiong Bao
Institutions
- Sun Yat-sen University (CN)
- Fifth Affiliated Hospital of Sun Yat-sen University (CN)
- Sun Yat-sen University Cancer Center (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
Publication Details
- Journal
- iMetaOmics.
- Published
- 2025-06-29
- DOI
- https://doi.org/10.1002/imo2.70039
- Primary Topic
- CRISPR and Genetic Engineering
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China