Optimizing Vancomycin Area under the Concentration-Time Curve Targets in Enterococcal Bacteremia: Balancing Efficacy and Nephrotoxicity
Nephrotoxicity and multiple comorbidities were stronger risk factors for unfavorable outcomes than vancomycin AUC/MIC. These findings highlight the need for individualized strategies to optimize efficacy while minimizing toxicity. Further large-scale studies are warranted to refine the optimal AUC/MIC threshold.
Authors
- Hakjun Hyun (ORCID: https://orcid.org/0000-0002-1193-8948)
- Young Rong Kim (ORCID: https://orcid.org/0000-0001-9422-4440)
- Young Hwa Choi (ORCID: https://orcid.org/0000-0001-5254-3101)
- Jung Yeon Heo (ORCID: https://orcid.org/0000-0002-6548-1939)
- Ha-Jin Chun (ORCID: https://orcid.org/0000-0002-6061-3832)
- Eun Jin Kim (ORCID: https://orcid.org/0000-0001-7008-0497)
Institutions
- Ajou University Hospital (KR)
- Ajou University (KR)
Publication Details
- Journal
- Yonsei Medical Journal
- Published
- 2025-01-01
- DOI
- https://doi.org/10.3349/ymj.2024.0513
- Citations
- 1
- Primary Topic
- Antimicrobial Resistance in Staphylococcus
- Type
- article
- Field-Weighted Citation Impact
- 1.40