Transcranial Optogenetic Stimulation Promotes Corticospinal Tract Axon Regeneration to Repair Spinal Cord Injury by Activating the JAK2/STAT3 Pathway
The modified transcranial optogenetic technique stimulated bilateral motor cortices, in the brains of ChR2-YFP transgenic mice. It increased the excitability of pyramidal neurons in the motor cortices, and promoted CST axon regeneration by activating the JAK2/STAT3 pathway, repairing complete SCI.
Authors
- Bi‐Qin Lai (ORCID: https://orcid.org/0000-0003-1978-3466)
- Yuan‐Shan Zeng (ORCID: https://orcid.org/0000-0003-3804-5792)
- Yue Lan (ORCID: https://orcid.org/0000-0003-2499-812X)
- Hong-Ying Chen
- Lizhi Peng
- Yuan‐Huan Ma (ORCID: https://orcid.org/0000-0001-9800-8139)
- Xiang Zeng (ORCID: https://orcid.org/0000-0003-4577-749X)
- Qing-shuai Wei
- Ying Ding (ORCID: https://orcid.org/0000-0003-0862-2309)
- Qingwen Deng (ORCID: https://orcid.org/0000-0003-1443-6860)
- Laijian Wang (ORCID: https://orcid.org/0000-0002-6513-1859)
- Ge Li (ORCID: https://orcid.org/0000-0001-9030-884X)
- Zhou Liu (ORCID: https://orcid.org/0000-0002-5698-3945)
- Bin Jiang
- Kun Zhang (ORCID: https://orcid.org/0009-0008-9791-3530)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Sun Yat-sen University (CN)
- Guangdong Medical College (CN)
- Nantong University (CN)
- Guangzhou First People's Hospital (CN)
- South China University of Technology (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Neurospine
- Published
- 2025-06-29
- DOI
- https://doi.org/10.14245/ns.2449312.656
- Citations
- 7
- Primary Topic
- Transcranial Magnetic Stimulation Studies
- Type
- article
- Field-Weighted Citation Impact
- 5.90
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province
- Guangzhou First People's Hospital