MARKERS OF ENDOTHELIAL DYSFUNCTION IN CHILDREN WITH OBESITY

Endothelial dysfunction plays a leading role in the progression of cardiovascular disease in children with obesity. The article discusses the prognostic values of early markers of endothelial dysfunction in children with obesity. The aim of the study: to study early markers of endothelial dysfunction in children and adolescents with abdominal obesity to predict the development of cardiovascular risk. Materials and methods: A total of 56 obese children aged 10-18 years were examined on an outpatient basis. Anthropometric, general clinical and biochemical studies of the lipid and carbohydrate spectrum were performed in all study groups. The levels of leptin, trimethylamine-N-oxide (TMAO) and von Willebrand factor (vWF) were determined in plasma by enzyme-linked immunosorbent assay (ELISA). Study results: A close relationship between severe obesity in children with hyperleptinemia and leptin resistance was revealed. The highest values ​​of the von Willebrand factor content and TMAO level were found in children with abdominal obesity. In children with a uniform type of obesity, these indicators had moderate values. Conclusion: Leptin resistance, elevated levels of TMAO and von Willebrand factor lead to endothelial dysfunction and, accordingly, a high risk of developing cardiovascular pathology in children with abdominal obesity.