Probability of pharmacokinetic/pharmacodynamic target attainment for different piperacillin/tazobactam dosing regimens in renally impaired patients in a non‐intensive care unit setting
Dosing according to the SmPC is only sufficient to achieve a conservative PK/PD target. In comparison, simulating an increased dosing with continuous administration attained an aggressive PK/PD target. Offering alternative dosing regimens may be of interest for severe infections with difficult to treat foci caused by Pseudomonas aeruginosa even in non-intensive care unit patients.
Authors
- Paul Schellong (ORCID: https://orcid.org/0000-0002-5382-0083)
- Max Kurlbaum (ORCID: https://orcid.org/0000-0002-8438-2127)
- Oliver Scherf‐Clavel (ORCID: https://orcid.org/0000-0002-1967-9231)
- Stefan Hagel (ORCID: https://orcid.org/0000-0003-2999-6131)
- Güzin Surat
- Emma Dohmann
Institutions
- University of Würzburg (DE)
- Universitätsklinikum Würzburg (DE)
- Jena University Hospital (DE)
- Friedrich Schiller University Jena (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- British Journal of Clinical Pharmacology
- Published
- 2025-06-29
- DOI
- https://doi.org/10.1002/bcp.70153
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 0.00